Nizochem (Ketoconazole)

Description: Ketoconazole, an imidazole antifungal agent, inhibits fungal CYP450 activity, thereby decreasing ergosterol biosynthesis and inhibiting fungal cell membrane formation. It also inhibits some fungal enzymes resulting in the accumulation of toxic concentrations of hydrogen peroxide.

Ketoconazole is also a potent cortisol and aldosterone synthesis inhibitor due to its ability to block several CYP450 enzymes in the adrenal glands.