A more accurate test to identify those truly at risk of preterm labour.
The PartoSure® test is a rapid, qualitative test for detecting the presence of placental alpha microglobulin 1 (PAMG-1) in cervicovaginal secretions in pregnant women with signs and symptoms of early preterm labour.
The PartoSure® test detects the protein PAMG-1 . PAMG-1 is a placental protein found in high concentrations in the amniotic cavity. Due to the low concentration of PAMG-1 in normal vaginal discharge, studies have demonstrated a strong correlation between a positive PAMG-1 test and imminent delivery in patients presenting with threatened PTL and intact membranes.
The importance of preterm labour diagnosis
Accurately assessing the risk of preterm birth is a difficult diagnosis with significant implications. Clinical evaluation alone is limited in its ability to predict imminent delivery among patients with signs of threatened preterm labour (PTL).
According to ACOG guidelines, traditional biomarker tests, such as those based on the detection of fetal fibronectin (fFN), are reported to have poor positive predictive values (PPV) for imminent delivery. The increased chance of false positives, indicated by a lower PPV, can lead to unnecessary admissions and interventions.
- 28% of patients presenting with signs and symptoms of threatened preterm labour may be admitted to the hospital.
- Studies show 7% to 20% of patients admitted deliver within 7 days4.